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Abstract #1930

In Vivo CEST-Based Molecular Imaging Using RGD-LipoCEST in U87 Mice Brain Tumor

Julien Flament1, Benjamin Marty1, Cline Giraudeau1, Sbastien Mriaux1, Julien Valette1, Christelle Mdina2, Caroline Robic2, Marc Port2, Franck Lethimonnier1, Gilles Bloch1, Denis Le Bihan1, Fawzi Boumezbeur1

1NeuroSpin, IBM, Commissariat l'Energie Atomique, Gif-sur-Yvette, France; 2Guerbet, Research Division, Roissy-Charles de Gaulle, France

LipoCEST are a new class of contrast agents for CEST-MRI which provide a tremendous amplification factor and can be easily functionalized by grafting specific peptide on their outer membrane in order to target pathology specific biomarker. We present our promising preliminary result to image αvβ3, integrin expressed during tumor growth, with CEST-based MRI using RGD-LipoCEST contrast agents. It constitutes to our knowledge the first attempt towards brain tumor detection using LipoCEST contrast agents in vivo.