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Abstract #1937

Creation of an Multimeric Anti-P53 ScTCR-SPIO Conjugate for the Detection of Cancer in MR

Richard Wong1,2, Tian Liu1,2, Xiao-Yun Zhu3, Hing C. Wong3, Yi Wang1,4

1Cornell University, Ithaca, NY, United States; 2Department of Radiology, Cornell University - Weill Medical College, New York, NY, United States; 3Altor Bioscience Corp, Miramar, FL, United States; 4Department of Radiology, Weill Medical College, New York, NY, United States

We have created an anti-p53 scTCR-SPIO for use as a generalized cancer detection contrast agent for use in MR. In vitro models demonstrate the effectiveness of this molecule in labeling p53-expressing cells and suggests future application in in vivo cancer models.