HKF Mak1,
Queenie Chan2, Zhipeng Zhang1, Esben Petersen3,
Deqiang Qiu1, Xavier Golay4, Leung-Wing Chu5
1Diagnostic Radiology, University of
Hong Kong, Hong Kong, Hong Kong; 2Philips Healthcare; 3Clinical
Imaging Research Centre, National University of Singapore, Singapore,
Singapore; 4UCL Institute of Neurology, Univeristy College of
London, United Kingdom; 5Medicine, University of Hong Kong, Hong Kong
Arterial
Spin Labeling MRI is a non-invasive method in studying cerebral blood flow,
which can be used as an indirect marker of glucose metabolism. In our local
Chinese cohort of 13 Alzheimer's disease (mean age- 76.3, MMSE- 16.3) and 15
cognitively normal elderly adults (mean age- 70.8, MMSE- 28.4), QUASAR
sequence showed impaired cerebral blood flow in middle & posterior
cingulate, bilateral inferior frontal, bilateral superior frontal, right
inferior parietal and left superior temporal gyri in AD as compared to
controls. This distribution of perfusion impairment is characteristic of
moderate Alzheimers disease, analogous to regional hypometabolism in
Positron Emission Tomography.
Keywords