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Abstract #1942

Cerebral Blood Flow in Alzheimer's Disease by Arterial Spin Labeling QUASAR

HKF Mak1, Queenie Chan2, Zhipeng Zhang1, Esben Petersen3, Deqiang Qiu1, Xavier Golay4, Leung-Wing Chu5

1Diagnostic Radiology, University of Hong Kong, Hong Kong, Hong Kong; 2Philips Healthcare; 3Clinical Imaging Research Centre, National University of Singapore, Singapore, Singapore; 4UCL Institute of Neurology, Univeristy College of London, United Kingdom; 5Medicine, University of Hong Kong, Hong Kong

Arterial Spin Labeling MRI is a non-invasive method in studying cerebral blood flow, which can be used as an indirect marker of glucose metabolism. In our local Chinese cohort of 13 Alzheimer's disease (mean age- 76.3, MMSE- 16.3) and 15 cognitively normal elderly adults (mean age- 70.8, MMSE- 28.4), QUASAR sequence showed impaired cerebral blood flow in middle & posterior cingulate, bilateral inferior frontal, bilateral superior frontal, right inferior parietal and left superior temporal gyri in AD as compared to controls. This distribution of perfusion impairment is characteristic of moderate Alzheimers disease, analogous to regional hypometabolism in Positron Emission Tomography.