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Abstract #1944

Parental History of Alzheimer Disease Predicts Abnormal White Matter in Cognitively Normal Elderly Individuals

Joseph Mettenburg1, David N. Daniels1, Beau Ances2, Huiling Peng2, Joshua Shimony1, Abraham Z. Snyder1, John C. Morris2, Mark A. Mintun1, Tammie L.S. Benzinger3

1Mallinckrodt Institute of Radiology, Washington University in Saint Louis; 2Neurology, Washington University in Saint Louis; 3Mallinckrodt Institute of Radiology, Washington University in Saint Louis, St. Louis, MO, United States

DT-MRI was performed on cognitively normal adults with and without a family history of dementia of the Alzheimers type (DAT). Regional differences were identified in the corpus callosum and parietal white matter in those individuals with confirmed parental history of DAT. These findings support the hypothesis that white matter abnormalities precede the clinically apparent onset of dementia, representing either early pathophysiological changes or fundamental differences in white matter integrity which may place individuals at risk for subsequent development of Alzheimer Disease.