Resting State Functional Patterns in AD and Their Correlation with Regional Amyloid-β Distribution.

Ernesto Sanz-Arigita¹, Nelleke Tolboom², Jolanda Boverhoff², A.A. Lammertsma², R. Boellaard², M. Yaqub², A.D. Windhorst², Cornelius S. Stam³, Philip Scheltens⁴, Frederik Barkhof⁵, Bart van Berckel²

Alzheimer-related differences in basal functional brain networks are likely be related to the regional distribution of neuropathology. To explore this relationship, we have scanned the same population of AD patients and age-matched controls both with fMRI in resting state condition and PET, employing two different amyloid-b tracers: 11C-PIB reveals the distribution of neurofibrillary tangles and 18F-FDDNP binds predominantly to amyloid plaques. The functional networks affected in AD, and the distribution of neuropathology largely overlaps. We will demonstrate the specific relationship between either type of amyloid pathology and particular functional networks.