Christine
Preibisch1, Annette Frschler1, Afra Wohlschlger1,
Christian Sorg2, Timo Grimmer2, Hans Frstl2,
Alexander Kurz2, Claus Zimmer1, Panagiotis Alexopoulos2
1Abteilung fr Neuroradiologie, Klinikum
rechts der Isar der Technischen Universitt Mnchen, Munich, Germany; 2Klinik
und Poliklinik fr Psychiatrie und Psychotherapie, Klinikum rechts der Isar
der Technischen Universitt Mnchen, Munich, Germany
Problem:
PASL was used to study cerebral perfusion changes in patients with MCI and
AD. Methods: Resting CBF maps were obtained from 16 young (3010a) and 15
elderly (655a) cognitively normal controls, 13 patients with MCI (699a) and
7 patients with mild dementia in AD (70.911.2a). Results: Hypoperfusion was
detected in parietal cortex and right angular gyrus when patients were
compared to controls. A significant perfusion decrease in parietal cortex and
left caudate was also detected in elderly compared to young controls.
Conclusion: This suggests that PASL is capable to investigate the transition
from normal ageing to dementia.