Christine Preibisch1, Annette Frschler1, Afra Wohlschlger1, Christian Sorg2, Timo Grimmer2, Hans Frstl2, Alexander Kurz2, Claus Zimmer1, Panagiotis Alexopoulos2
1Abteilung fr Neuroradiologie, Klinikum rechts der Isar der Technischen Universitt Mnchen, Munich, Germany; 2Klinik und Poliklinik fr Psychiatrie und Psychotherapie, Klinikum rechts der Isar der Technischen Universitt Mnchen, Munich, Germany
Problem: PASL was used to study cerebral perfusion changes in patients with MCI and AD. Methods: Resting CBF maps were obtained from 16 young (3010a) and 15 elderly (655a) cognitively normal controls, 13 patients with MCI (699a) and 7 patients with mild dementia in AD (70.911.2a). Results: Hypoperfusion was detected in parietal cortex and right angular gyrus when patients were compared to controls. A significant perfusion decrease in parietal cortex and left caudate was also detected in elderly compared to young controls. Conclusion: This suggests that PASL is capable to investigate the transition from normal ageing to dementia.