Natalie L.
Voets1,2, Boris C. Bernhardt2, Hosung Kim2,
Andrea Bernasconi2
1University of Oxford FMRIB Centre,
Oxford, Oxfordshire, United Kingdom; 2Montreal Neurological
Institute and Hospital, McGill University, NeuroImaging of Epilepsy
Laboratory and McConnell Brain Imaging Centre, Montreal, Quebec, Canada
Converging
histological and radiological data suggest neurodevelopmental abnormalities
may play a role in the pathogenesis of drug-resistant temporal lobe epilepsy
(TLE). Using surface-based cortical curvature measures, we identified
abnormally increased cortical folding in the left temporal pole of patients
with both left and right TLE as compared to healthy controls. Increased left
temporopolar folding was associated with abnormal positioning of the
ipsilateral hippocampus in left TLE patients, and associated with
unfavourable surgical outcome in patients with a right-sided seizure focus.
These results suggest abnormalities in global limbic network connectivity may
play an important role in temporal lobe epileptogenesis.
Keywords