Abstract #1974

31P and 1H MR Spectroscopic Studies on Changes of Cerebral Brain Metabolism Induced by Alcoholism and Detoxification

Ulrich Pilatus¹, Joerg Magerkurth¹, Nicole Schwan², Tilmann Wetterling², Barbara Schneider²

¹Institute of Neuroradiology, University Hospital, Goethe-University, Frankfurt, Germany; ²Department of Psychiatry, University Hospital, Goethe-University

Cerebral metabolites at day 1 and day 7 of alcohol detoxification therapy were studied using 1H and 31P spectroscopic imaging. Particularly for prefrontal brain, metabolite concentrations correlated with the withdrawal syndrome. The results suggest that less severe symptoms support neuronal recovery while a less pronounced deviation from control values for energy or membrane related compounds is correlated with more severe symptoms.