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Abstract #1975

Schizophrenia Impact on Perfusion Parameters: A Dynamic Susceptibility Contrast Magnetic Resonance Imaging Study.

Denis Peruzzo1, Gianluca Rambaldelli2,3, Alessandra Bertoldo1, Marcella Bellani2,3, Roberto Cerini4, Sivlia Marini5, Roberto Pozzi Mucelli5, Michele Tansella2,3, Paolo Brambilla6,7

1Department of Information Engineering, University of Padova, Padova, Italy; 2Inter-University Center for Behavioural Neurosciences, University of Verona, Verona, Italy; 3Department of Medicine and Public Health, University of Verona, Verona, Italy; 4Service of Radiology, Policlinico GB Rossi Hospital, Verona, Italy; 5Department of Morphological and Biomedical Sciences, University of Verona, Verona, Italy; 6Inter-University Center for Behavioural Neurosciences, University of Udine, Udine, Italy; 7Scientific Institute, IRCCS E. Medea, Udine, Italy

Abnormalities of Cerebral Blood Flow (CBF) and Volume (CBV) have been observed in schizophrenia patients, suggesting that a disruption of the vascular system may occur in this disease. However, cerebral perfusion is also influenced by several physiologic parameters, not necessarily connected to the pathology. We performed a DSC-MRI analysis to study the role of the demographic information on perfusion parameter estimates between patients with schizophrenia and normal control subjects. We found that differences (i.e. between-subject variability) in CBF and CBV are partially explained by the age and/or by a difference in the subject health conditions.