Denis Peruzzo1, Gianluca Rambaldelli2,3, Alessandra Bertoldo1, Marcella Bellani2,3, Roberto Cerini4, Sivlia Marini5, Roberto Pozzi Mucelli5, Michele Tansella2,3, Paolo Brambilla6,7
1Department of Information Engineering, University of Padova, Padova, Italy; 2Inter-University Center for Behavioural Neurosciences, University of Verona, Verona, Italy; 3Department of Medicine and Public Health, University of Verona, Verona, Italy; 4Service of Radiology, Policlinico GB Rossi Hospital, Verona, Italy; 5Department of Morphological and Biomedical Sciences, University of Verona, Verona, Italy; 6Inter-University Center for Behavioural Neurosciences, University of Udine, Udine, Italy; 7Scientific Institute, IRCCS E. Medea, Udine, Italy
Abnormalities of Cerebral Blood Flow (CBF) and Volume (CBV) have been observed in schizophrenia patients, suggesting that a disruption of the vascular system may occur in this disease. However, cerebral perfusion is also influenced by several physiologic parameters, not necessarily connected to the pathology. We performed a DSC-MRI analysis to study the role of the demographic information on perfusion parameter estimates between patients with schizophrenia and normal control subjects. We found that differences (i.e. between-subject variability) in CBF and CBV are partially explained by the age and/or by a difference in the subject health conditions.