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Abstract #1996

Amygdala Network Dysfunction Links Depressive Symptom and Memory Deficit in Elderly with Amnesic Mild Cognitive Impairment

Chunming Xie1,2, Wenjun Li1, Joseph Goveas1, Piero Antuono1, Jennifer Jones1, Guangyu Chen1, Malgorzata Franczak1, Zhilin Wu1, Shi-Jiang Li1

1Medical College of Wisconsin, Milwaukee, WI, United States; 2Neurology, School of Clinical Medicine, Southeast University, Nanjing, Jiangsu, China

The purpose of this study was to identify neural correlates of depressive symptoms and memory deficits in the amygdala functional connectivity network (AFCN) in elderly with or without amnesic mild cognitive impairment (aMCI) using the resting state functional connectivity MRI technique. aMCI subjects showed abnormal AFCN activity and the significant different correlation patterns in the distinct nodes within the AFCN correlated to depressive symptoms and memory deficits. This suggests the AFCN has dual effects that link depressive symptoms and memory deficits. The altered neural substrates of the AFCN underlying the emotional and cognitive functions mediation were associated with disease state.