Rachel Sharkey1,2, Robert Karl Kosior,
1,3, Paolo Federico1,2, Richard Frayne, 12
1Seaman Family MR Research Centre,
Foothills Medical Centre, Calgary, AB, Canada; 2Radiology and
Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary,
Calgary, AB, Canada; 3Biomedical Engineering, University of
Calgary, Calgary, AB, Canada
Our
objective was to assess the effect of age on T2 for voxel-based relaxometry
(VBR) analysis. Regressions of T2 versus age were run on data from healthy
controls with a voxel-based analysis and with regions of interest. For
controls and epileptic patients, VBR was performed once with age included as
a nuisance variable, and once without. The correlation was variable across
the brain, and significant (p < 0.05) in four regions, including the
hippocampus (decreasing T2 with age). Without adjusting for age,
discrepancies in VBR findings are found in younger and older patients.