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Abstract #2003

Novel Atlas-Based Technique for Longitudinal Investigation of Diffusion Tensor Tractography Data: Application to Healthy Ageing

Ai Wern Chung1, Rebecca A. Charlton1, Nigel C. Lawes2, Robin G. Morris3, Hugh S. Markus1, Thomas R. Barrick1

1Centre for Clinical Neuroscience, Saint George's University of London, London, United Kingdom; 2Graduate Medical School, University of Limerick, Limerick, Ireland; 3Department of Psychology, Institute of Psychiatry, King's College University of London, London, United Kingdom

We present a novel technique applying probabilistic diffusion tensor tractography on longitudinal data to assess white matter structural integrity in ageing subjects over a period of two years. Our method was able to consistently extract white matter tracts associated with working memory over time and between two ageing cohorts (middle-aged and elderly). Tract connections were found between the fronto-temporal, fronto-parietal and temporo-parietal lobes. Our study suggests a decrease in white matter structural integrity of these tracts with age could be related to the decline in working memory performance.