Mark E. Bastin1, Maria Valds Hernandez2,
Susana Muoz Maniega2, Catherine Murray3, Alan J. Gow3,
Paul A. Armitage2, Joanna M. Wardlaw2, Ian J. Deary3
1Medical Physics, University of
Edinburgh, Edinburgh, United Kingdom; 2Clinical Neurosciences,
University of Edinburgh, Edinburgh, United Kingdom; 3Psychology,
University of Edinburgh, Edinburgh, United Kingdom
White
matter lesions are a common finding on T2- and FLAIR-weighted MRI scans of
older subjects, but their etiology and relationship to cognitive function
remains unclear. The aim of this pilot study was to characterize differences
in magnetization transfer ratio and spin-lattice relaxation time between
macroscopically normal-appearing white matter and white matter lesions in a
subset of a unique cohort of aging subjects, the Lothian Birth Cohort 1936.
Keywords