Zhengjun Li1,2, Aniseh Kadivar3,
John Pluta3, Holly D. Soares4,
1Dept. of Biomedical Engineering,
Shanghai Jiao Tong University, China; 2Dept of Psychiatry,
University of Pennsylvania, United States; 3Dept of Neurology,
University of Pennsylvania, United States; 4Pfizer Inc, United
States; 5Dept of Psychiatry, University of Pennsylvania,
Philadelphia, PA, United States
Functional
connectivity (FC) and the default mode network represents two recent active
research directions in fMRI. Previous studies have shown the aging effect in
resting FC based on independent component analysis or concurrent task
involved fMRI defined region-of-interests (ROIs). No published work has
assessed the aging effects on resting FC in the DMN using the seed region
based method. To meet this gap, we here report some preliminary results of
the aging inter-region FC in the normal brain using resting fMRI and found age-dependent
FC decrease in anterior cingulate cortex and posterior cingulate cortex.
Keywords