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Abstract #2009

Aging Effects on the Functional Connectivity in the Resting Brain

Zhengjun Li1,2, Aniseh Kadivar3, John Pluta3, Holly D. Soares4, Murray Grossman3, John Detre3, Ze Wang5

1Dept. of Biomedical Engineering, Shanghai Jiao Tong University, China; 2Dept of Psychiatry, University of Pennsylvania, United States; 3Dept of Neurology, University of Pennsylvania, United States; 4Pfizer Inc, United States; 5Dept of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States

Functional connectivity (FC) and the default mode network represents two recent active research directions in fMRI. Previous studies have shown the aging effect in resting FC based on independent component analysis or concurrent task involved fMRI defined region-of-interests (ROIs). No published work has assessed the aging effects on resting FC in the DMN using the seed region based method. To meet this gap, we here report some preliminary results of the aging inter-region FC in the normal brain using resting fMRI and found age-dependent FC decrease in anterior cingulate cortex and posterior cingulate cortex.