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Abstract #2052

Diffusion MRI Detects Different Developmental Trajectory in the Thalamus of Adolescents with Attention-Deficit Hyperactivity Disorder (ADHD) Compared with Typically Developing Controls

Maria Fatima Falangola1,2, Vitria Adisetiyo1, Wende R. Gelb1, Jens H. Jensen1, Caixia Hu1, Ali Tabesh1, Francisco X. Castellanos3, Adriana DiMartino3, Joseph A. Helpern1,2

1Radiology, New York University Langone Medical Center, New York, NY, United States; 2Center for Advanced Brain Imaging, Nathan Kline Institute, Orangeburg, NY, United States; 3Child Study Center, New York University Langone Medical Center, New York, NY, United States

Since the neuroanatomical basis of attention deficit-hyperactivity disorder (ADHD) is postulated to involve the frontal cortical-basal ganglia-thalamic-cerebellar circuits, we decided to examine the microstructural integrity of the thalamus in adolescents with ADHD using diffusion MRI, including a new technique called diffusional kurtosis imaging (DKI). We report that for a typically developing adolescent (12-18 yr), there are age-related diffusion changes in the thalamus, but no diffusion changes in the ADHD group, which suggest that there may be a difference in the trajectories of structural development in the thalamus between typically developing and ADHD adolescents.