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Abstract #2053

Cerebellar Vermis Impairment in Children Treated for Brain Malignancies

Alena Horska1, Ashley LaClair2, Mona Mohamed1, Carolyn T. Wells3, Todd McNutt1, Moody Wharam1, E Mark Mahone4, Wendy Kates2

1Johns Hopkins University, Baltimore, MD, United States; 2SUNY Upstate Medical University, Syracuse, NY, United States; 3Children's National Medical Center, Rockville, MD, United States; 4Kennedy Krieger Institute, Baltimore, MD, United States

The goal of this prospective longitudinal study in children receiving brain radiation involving the cerebellum was to evaluate vermal volumes and performance on neuropsychological tests associated with cerebellar function. In patients, lower mean vermal volumes and impaired performance on visual-spatial and fine motor tasks were detected at baseline. At 6-months post-radiation, further decrease in vermal volumes was detected in medulloblastoma patients; the vermal volumes decrease was not associated with reduction in neuropsychological performance compared to baseline. Regression analyses of the 6-months follow-up data from all subjects revealed better performance on the Purdue Pegboard tests with larger vermal volumes.