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Abstract #2056

Measurement of Brain Water in Children During and After Treatment for Diabetic Ketoacidosis

Michael H. Buonocore1, Sandra L. Wootton-Gorges2, Nathan Kuppermann3, Ryan Caltagirone, Nicole S. Glaser

1Radiology, UC Davis Imaging Research Center, Sacramento, CA, United States; 2Radiology, UC Davis Medical Center, Sacramento, CA, United States; 3Emergency Medicine and Pediatrics, UC Davis Medical Center, Sacramento, CA, United States

The purpose of this study was to measure brain water in children undergoing treatment for DKA to assess cerebral edema. Brain water was measured on a 3T system using FSPGR scans with five different flip angles, followed by non-linear curve fitting to derive proton density (M0) maps, and calibrating regional M0 map values with the values from 100% water reference vials placed within the imaged volume. Results from seven children suggest that regional brain water is elevated early in the course of treatment, confirming a degree of cerebral edema. Edema increases during the course of treatment with fluids and insulin, and then resolves after the child recovers.