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Abstract #2057

Regional Grey-White Matter Volume Abnormalities in Children with Histories of Early Deprivation

Jeong-Won Jeong1,2, Michael Behen1,2, Piti Sinsoongsud1,2, Otto Muzik, 2,3, Benjamin Wilson1,2, Harry T. Chugani, 2,3

1Pediatrics and Neurology, Wayne State University, Detroit, MI, United States; 2PET center, Children's Hospital of Michigan, Detroit, MI, United States; 3Pediatrics, Neurology, and Radiology, Wayne State University, Detroit, MI, United States

A previous 18FDG-PET study revealed that children with histories of institutional rearing showed significantly decreased glucose metabolism in neumerous brain regions. Dysfunction in these regions may result from severe stress of early deprivation. This study presents an atlas-based analysis to assess specific volumetric changes in predefined brain regions of the children with histories of early deprivation and examines associations between regional findings and cognitive, socioemotional, and behavioral difficulties that commonly are observed in the orphans. Significant bilateral volume reduction in grey-white matter was observed in the orphan group. It was highly correlated with their externalizing behavioral deficit and perceptual functioning.