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Abstract #2062

Surface Deformation-Based Analysis of Regional Shape Variations of Hippocampus in Children with FAS

Jesu Christopher Joseph1, Anton Eicher2, Christopher Warton1, Sandra W Jacobson3, Joseph L Jacobson3, Christopher D Molteno, Patrick Marais2, Ernesta M Meintjes1

1Human Biology, University of Cape Town, Cape Town, Western Cape, South Africa; 2Computer Science, University of Cape Town, Cape Town, Western Cape, South Africa; 3Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, United States

The main objective of this work is to assess the shape variations of the hippocampus structure between control and FAS affected children. For this High-resolution structural MRI images were acquired of 12 children aged 9-12 years on a 3T Siemens Allegra Scanner (6 controls and 6 FAS). Hippocampi were manually delineated. The entire structure of the hippocampus was divided into three regions, namely head, body and tail. A point distribution model, which represents the mean geometry of a shape using landmark points, was used to capture the true geometry of the hippocampus. Approximately 2366 landmark points were used. Principal Component Analysis (PCA) was used to study correlations of movement between groups of landmark points among the control children who were used as the training set and to assess the geometric variations between the healthy and exposed subjects.