Abstract #2063

A Realistic Model of Brain Tissue in Case of Hydrocephalus: Application of MRI, DTI and MRE

Kamal Shahim¹, Ralph Sinkus², Jean-Marie Drezet¹, Shahan Momjian³, jean-francois Molinari⁴

¹LSMX, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland; ²Laboratoire Ondes et Acoustique, ESPCI, Paris, France; ³University Hospitals of Geneva and University of Geneva, Switzerland; ⁴LSMS, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland

Hydrocephalus is a cerebral disease wherein the brain ventricles dilate and the parenchyma is stressed. In order to study this condition, a finite element model is built using the geometries of the ventricles and the skull measured by MRI. DTI is used to establish the fiber direction and the local frame. Indeed, elasticity data based on MRE is incorporated into the constitutive equation. The brain parenchyma is modeled as a porous medium. Under an applied pressure gradient, Isotropic and Transverse Isotropic models are tested and compared together. The transmission of the applied pressure is substantially influenced by the anisotropy and inhomogeneity of brain parenchyma.