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Abstract #2077

Pre-Filling MS Lesions on T1 and T2-Weighted Images for Improved Tissue Segmentation

Jonathan S. Jackson1,2, Declan Chard2, Antonia Ceccarelli1, Elisa Dell'Oglio1, Ashish Arora1, Mohit Neema1, Rohit Bakshi1, David Miller2, Claudia Angela Michela Wheeler-Kingshott2

1Laboratory for Neuroimaging Research, Brigham & Women's Hospital, Harvard Medical School, Brookline, MA, United States; 2Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom

Robust lesion in-painting has been demonstrated on T1 and T2-weighted images. Many automated algorithms rely on accurate histograms for segmentation; therefore this approach to lesion WM correction based on the global histogram is appropriate and strongly recommended as a pre-processing step for MS images.