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Abstract #2080

Altered Brain Perfusion and Tissue Injury in Early Multiple Sclerosis Assessed by ASL and MTR Statistical Mapping Analyses

Wafaa Zaaraoui1, Franoise Reuter1, Mathias Lemaire1, Audrey Rico1, Anthony Faivre1, Virginie Callot1, Irina Malikova1, Elisabeth Soulier1, Sylviane Confort-Gouny1, Patrick J. Cozzone1, Jean Pelletier1, Bertrand Audoin1, Jean-Philippe Ranjeva1

1Facult de Mdecine, CRMBM UMR CNRS 6612, Marseille, France

Recent studies have evidenced the crucial role of perfusion alteration in multiple sclerosis (MS). However, little is known about the relationships between hemodynamical parameters and local tissue damage encountered at all stages of the disease, and especially at the early phase. To investigate the putative relationships between perfusion alterations and structural local white matter and grey matter impairments in early MS, we designed a MR protocol combining statistical mapping analyses of arterial spin labeling (ASL) data and magnetization transfer ratio (MTR) data obtained in 12 patients with clinically isolated syndromes (CIS) and 12 matched controls.