Ryan Griffin1, Adam Brandenberry1,
Jiachao Liang1, Christopher Murphy1,
1Radiology, The
The
purpose of this study was to use Dynamic Contrast Enhanced MRI at 3T to
quantitatively study the perfusion of MS lesions. Using Brixs two
compartment model, we found statistically significant differences in the mean
extracted values of the pharmacokinetic values Amp and kel
of enhancing lesions with respect to those from normal appearing brain
tissue, as well as a statistically significant difference in the mean
extracted value of Amp from
hypointense lesions with respect to normal appearing brain tissue. Rising enhancement after the initial uptake
of gadolinium (indicated by a negative kel
value) was observed for every enhancing lesion.
Keywords