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Abstract #2090

Absolute Quantification of Myelin Related Volume in the Brain

J. B.M. Warntjes1, J. West1,2, A. M. Landtblom1,3, P. Lundberg2

1Center for Medical Imaging Science and Visualization (CMIV), Linkping, Sweden; 2Department of Medicine and Health, Division of radiation physics, Linkping, Sweden; 3Department of Clinical Neuroscience, Linkping, Sweden

A method is described to measure the myelin related volume fraction for each voxel for a complete brain within a scan time of 5 to 6 minutes, based on absolute quantification of the relaxation rates R1 and R2 and proton density. The absolute decrease of visible PD with a simultaneous increase of R1 and R2 corresponds to an increase of myelin. Myelin related volume is correlated with Fractional Anisotropy maps and conventional T1W, T2W and FLAIR images. Repeated measurements show a standard deviation of 1-2% in myelin volume for the whole brain.