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Abstract #2091

Changes in Multiple Sclerosis Over 6 Months as Seen with T2 Relaxation and Diffusion Histograms

Irene Margaret Vavasour1, Shannon Heather Kolind2, Cornelia Laule1, Burkhard Maedler3, David K.B. Li1, Anthony L. Traboulsee4, Alex L. MacKay1,3

1Radiology, University of British Columbia, Vancouver, BC, Canada; 2FMRIB Centre, University of Oxford, Oxford, United Kingdom; 3Physics and Astronomy, University of British Columbia; 4Medicine, Univeristy of British Columbia

Twelve multiple sclerosis subjects and 12 healthy age and gender matched controls were scanned twice at a 6 month interval to compare histograms derived from normal white matter (NWM), normal appearing white matter (NAWM) and multiple sclerosis lesions. Myelin water fraction (MWF), geometric mean T2 (GMT2), fractional anisotropy, mean diffusivity and the eigenvalues were measured. Mean MWF and GMT2 histograms did not differ between the two time points although histograms from NWM, NAWM and lesions were different. Histograms from the diffusion metrics differed slightly between month 0 and 6. T2 relaxation and diffusion metrics give complementary information about MS tissue.