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Abstract #2093

Individual Voxel Based Analysis of Brain Magnetization Transfer Maps Evidences High Variability of Grey Matter Injury in Patients at the First Stage of Multiple Sclerosis

Lorena Jure1, Wafaa Zaaraoui1, Celia Rousseau1, Franoise Reuter1, Audrey Rico1, Irina Malikova1, Sylviane Confort-Gouny1, Patrick J. Cozzone1, Jean Pelletier1, Bertrand Audoin1, Jean-Philippe Ranjeva1

1CRMBM UMR CNRS 6612, Marseille, France

Various MR studies, based on group comparison have demonstrated a common pattern of grey matter (GM) injury in patients since the early stage of multiple sclerosis (MS). However, little is know about the potential variability of this early GM involvement which may determine the high variability of the functional prognosis. We propose an optimized method to obtain from statistical mapping analyses applied on MTR data, the GM MTR abnormalities of subjects at the individual level. Feasibility is demonstrated in early MS patients showing variable individual patterns of GM injury that could explain heterogeneity of clinical progression for this disease.