Kerstin Bendfeldt1, Louis Hofstetter, Pascal
Kuster, Stefan Traud, Nicole Mller-Lenke, Yvonne Naegelin, Ludwig Kappos,
Achim Gass, Thomas E. Nichols2, Frederik Barkhof3,
Stephan Roosendaal3, Jeroen Geurts3, Hugo Vrenken3,
Ernst-Wilhelm Radue, Stefan J. Borgwardt4
1University Hospital Basel, Basel,
Basel-Stadt, Switzerland; 2University of Warwick; 3University
of Amsterdam; 4Medical Image Analysis Centre, University Hospital
Basel, Basel, Basel-Stadt, Switzerland
We
used optimized voxel-based morphometry to study similarities and differences
of regional gray matter volume development in relapsing remitting and
secondary progressive MS. Although regional gray matter volume measures
reveal areas of significant gray matter volume loss in RRMS, the results from
this study suggest, that there is no marked acceleration in the progressive
phase of the disease. This implies that the more pronounced impact of gray
matter pathology in the secondary progressive phase is a result of longer
linear accrual of such damage, rather than a phase-specific acceleration.
Keywords