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Abstract #2095

Evidence of Subcortical Grey Matter Atrophy and Surface Morphology Differences in Primary Progressive Multiple Sclerosis

Rose Gelineau-Kattner1,2, Tarunya Arun1, Damian Jenkins1, Morgan Hough1, Jacqueline Palace3, Mark Jenkinson1

1FMRIB Centre, University of Oxford, Oxford, United Kingdom; 2Baylor College of Medicine, Houston, TX, United States; 3Clinical Neurology, Oxford University and Oxford Radcliffe Hospitals NHS Trust, United Kingdom

Grey matter damage is important in the pathology of Primary Progressive Multiple Sclerosis (PPMS). We scanned 22 patients and 7 controls at baseline, and 2, 50, and 52 weeks. FreeSurfer was used to segment subcortical grey matter and vertex analysis was performed with FSLs FIRST to identify differences in surface morphology between groups. Significant atrophy and correlations with EDSS and/or disease duration were seen in some structures at baseline and all structures showed volume reduction over one year. Surface morphology differences were found in the thalamus and pallidum. Results highlight importance of subcortical atrophy and structural morphology differences in PPMS.