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Abstract #2117

MR Relaxometry and Diffusion Tensor Imaging of Normal Appearing White Matter in Mild Traumatic Brain Injury.

Christopher James Andrew Cowie1,2, Benjamin S. Aribisala1, Jiabao He1, Joshua Wood1, Alexander David Mendelow2, Patrick Mitchell2, Andrew M. Blamire1

1Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, Tyne & Wear, United Kingdom; 2Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, Tyne & Wear, United Kingdom

Mild traumatic brain injury (mTBI) is associated with long term cognitive and affective symptoms. Findings on conventional MRI often do not account for the duration and severity of these symptoms. The aim of this study was to ascertain whether MR relaxometry and diffusion tensor imaging would reveal abnormalities in normal appearing white matter (NAWM) in patients with mTBI. Whole group analysis showed no significant differences, but after grouping the patients according to the side of the visible lesion, a significant increase in the mean diffusivity (MD) of ipsilateral frontal lobe NAWM was demonstrated.