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Abstract #2118

Quantification of DTT Metrics in Various Fiber Bundle in Patients with Frontal Lobe Injury and Its Correlation with Neuropsychological Tests

Manoj Kumar1, Deepa Pal1, Ram KS Rathore2, Bal K. Ojha3, Anil Chandra3, Raj Kumar3, Rakesh Kumar Gupta1

1Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2Mathematics and Statistics, Indian Institute of Technology, , Kanpur, Uttar Pradesh, India; 3Neurosurgery, Chhatrapati Shahuji Maharaj Medical University,, Lucknow, Uttar Pradesh, India

Diffusion tensor imaging (DTI) was performed within 7 days and after 6 months of injury in 21 traumatic brain injury (TBI) patients with frontal lobe injury and 21 age/sex matched controls. Diffusion tensor tractography (DTT) was proposed for quantification of various white matter (WM) tracts in patients with frontal lobe injury to assess diffuse axonal injury (DAI) and to look for correlation of these fiber bundles measures with various neuropsychological tests (NPT). We found reduced fractional anisotropy (FA) and increased mean diffusivity (MD) values in all WM tracts in TBI patients compared to controls, NPT scores were found to be significantly impaired in follow-up patients compare to controls and some of these tests showed significant correlation with DTI indices with different WM tracts. WM tracts which show significant difference on DTT were also correlated with those NPT which are associated with main function of frontal lobe such as memory, attention, visual and motor function. It appears more realistic methods for DAI quantification in TBI patients and provides information about structural integrity and connectivity of whole fiber tracts.