Wang Zhan1, Grant Gauger2, Lauren
Boreta1,
1Radiology and Medical Imaging,
University of California, San Francisco, San Francisco, CA, United States; 2VA
Medical Center, San Francisco
Fornix
is one of the primary white matter structures of the limbic system, and its
damage in mild traumatic brain injury (TBI) may explain the memory and
learning dysfunctions in the post-concussion syndrome. N=24 TBI patients were
longitudinally studied in two time points using T1 anatomical imaging and
diffusion tensor imaging (DTI) to measure the fornix-to-brain ratio (FBR) and
WM integrity of fornix, and compared with matched healthy controls. Our data
show that the WM degradation in fornix onset in the acute stage after mild
TBI, and that this degradation continued during the following 6-month period
of recovery.
Keywords