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Abstract #2120

Detection of Tissue Changes in Traumatic Brain Injury Patients Using Automatic Regional Analysis of Quantitative MR Scans

Benjamin Segun Aribisala1, Christopher J.A. Cowie1,2, Jiabao He1, Joshua Wood1, David A. Mendelow2, Patrick Mitchell2, Andrew M. Blamire1

1Institute of Cellular Medicine, Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, England, United Kingdom; 2Department of Neurosurgery, Newcastle General Hospital, Newcastle University, Newcastle upon Tyne, England, United Kingdom

Traumatic head injury is one of the major causes of neurological morbidity and mortality in the UK with more than 0.1 million admissions per year with primary diagnosis of head injury. This constitutes a huge drain on medical resources. Majority of these patients have ongoing symptoms which do not correlate with MRI or CT findings. Here we investigated a cohort of patients with mild TBI using multi-parametric real space analysis. Our results show that a fully automatic real space method of analysing quantitative MR parameters can be used to detect changes in normal appearing tissues in patients suffering mild TBI.