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Abstract #2121

Using Jacobean Determinants to Map Within-Subject Serial Changes in Brain Volume in Difficult Contexts: Implementation in Traumatic Brain Injury with Decompressive Craniectomy

Steve Sawiak1, Virginia FJ Newcombe2, M G. Abate2, Jo G. Outtrim2, John D. Pickard1, T A. Carpenter1, Guy B. Williams1, David K. Menon2

1Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; 2Division of Anaesthesia, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom

Atrophy is common post traumatic brain injury (TBI) and may correlate with outcome. We hypothesised that quantification of Jacobian determinants could assess progressive changes in brain volume in within subject analyses, even in contexts that produce major problems with comparative analyses. We show implementation of the approach in a single TBI subject with serial scans before and up to 12 months after decompressive craniectomy, compared to results from healthy controls. The results indicate it is possible to monitor the changes in brain volume over time post TBI in an individual.