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Abstract #2122

The Relationship of White Matter Lesion and Contract Enhanced Lesion Development Courses in Radiation Induced Brain Injury: An MRI Based Study

H Huang1,2, M Deng1, S F. Leung3, Y L. Chan1, D K. Yeung1, H C. Chan1, A T. Ahuja1, Y X. Wang1

1Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong; 2Department of Radiology, The Shenzhen Third Peoples Hospital, Shenzhen, China; 3Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital

The natural course of radiation induced brain injury still remains poorly understood. Among the abnormalities white matter edema-like lesions (WML) and contrast enhanced necrotic lesions (CEL) have been most commonly reported. It was recently reported that radiation induced brain injury was not always an irreversible and progressive process, but one that could show regression and resolution. In total 22 nasopharyngeal carcinoma patients with 36 lobes displaying WML and CEL were analysed in this study. The preliminary results of this study suggest the development of WML and CEL tend to follow the same pattern, and not develop in the opposite direction.