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Abstract #2136

Ex Vivo Visualization of Cortical Lesions in Non-Human Primates with MS Using Inversion Recovery Experiments

Erwin Lambert Blezer1, Yolanda S. Kap2, Jan Bauer3, Bert L. 't Hart2

1Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 2Department of Immunobiology, Biomedical Primate Research Center, Rijswijk, Netherlands; 3Brain Research Institute, University of Vienna, Vienna, Austria

Cortical pathology is an important feature of MS. However visualization with MRI is poor although sensitivity is increased using FLAIR and Double Inversion Recovery (suppression of CSF and white matter) experiments. Various inversion recovery experiments were tested ex vivo on brains of marmoset with MS, which develop cortical lesions, in their ability to improve cortical lesion detection. Experiments included settings of inversion times in which CSF, white or grey matter was suppressed and a DIR experiment in which both white and grey matter was suppressed. Cortical lesions were best visualized after suppression of white matter or in the DIR experiment.