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Abstract #2152

White Matter Abnormalities in Boys with Autism Spectrum Disorders: Preliminary Evidence from Diffusion Tensor Imaging

Sung-Yeon Park1, Se-Hong Oh1, Hyo-Woon Yoon1, Young-Bo Kim1, Zang-Hee Cho1, Keun-Ah Cheon2

1Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon, Korea, Republic of; 22Division of child and Adolescent Psychiatry, Department of Psychiatry, Kwandong University College of Medicine, Kyunggi-Do, Korea, Republic of

Autism spectrum disorders (ASD) are characterized by qualitative impairments of reciprocal social interaction and deficits in communication, and stereotyped or repetitive pattern of behavior. A few reports have shown the abnormalities of white matter in autism using diffusion tensor imaging (DTI), however there is still lack of evidence showing strong relation to abnormalities in white matter structural integrity with autism. We enrolled thirty four male subjects (17 ASD, 17 healthy controls, matched on age, IQ, handedness.). Our preliminary findings which showed significant reduction of FA in white matter structure related social cognition in ASD subjects compared control subjects support previous findings that social brain structure may be disrupted in ASD. These findings will help on understanding of more advanced neurobiological basis underlying the social deficits in ASD.