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Abstract #2153

Imaging Myelin in Autism

Janneke Zinkstok1, Eileen Daly1, Christine Ecker1, Patrick Johnston1, Shannon Kolind2, Declan Murphy1, Sean Deoni2

1Section of Brain Maturation, Institute of Psychiatry, London, United Kingdom; 2Centre of Neuroimaging Sciences, Institute of Psychiatry, London, United Kingdom

Using the novel Multi-Component Driven Equilibrium Single Pulsed Observation of T1 and T2 (mcDESPOT) method, we quantitatively compared myelin content between individuals with autism and healthy controls. We found significantly reduced myelin content in adults with autism in brain regions previously implicated in autism, including the body of the corpus callosum, and in frontal, temporal, parietal and occipital regions; and in white matter tracts including the left and right uncinate, the left inferior occipitofrontal tract, the left inferior cerebellar peduncle, the left arcuate, the right anterior segment, the left inferior and superior longitudinal fasciculus, and the posterior segments bilaterally.