Tzu-Chao Chuang1, Sheng-Po Huang1,
Pinchen Yang2, Ming-Ting Wu3,4
1Electrical Engineering, National Sun
Yat-Sen University, Kaohsiung, Taiwan, Taiwan; 2Psychiatry,
Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Taiwan; 3School
of Medicine, National Yang-Ming University, Taipei, Taiwan, Taiwan; 4Radiology,
Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan, Taiwan
In
this study, white matter abnormalities of attention-deficit hyperactivity
disorder were investigated using diffusion tensor imaging. Two different
algorithms, including the well-known voxel-based morphometry (VBM) method and
recently proposed tract-based spatial statistics (TBSS), were applied for
inter-subject comparison. 26 male adolescents (12 ADHD patients and 14
age-matching control subjects) were recruited in this study. Significant
decrease of FA was observed on white matter tracts widespread in a scattering
pattern by the use of both methods in patients compared to the control group.
Keywords