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Abstract #2154

Inter-Subject Comparison of Fractional Anisotropy in Attention-Deficit/hyperactivity Disorder

Tzu-Chao Chuang1, Sheng-Po Huang1, Pinchen Yang2, Ming-Ting Wu3,4

1Electrical Engineering, National Sun Yat-Sen University, Kaohsiung, Taiwan, Taiwan; 2Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Taiwan; 3School of Medicine, National Yang-Ming University, Taipei, Taiwan, Taiwan; 4Radiology, Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan, Taiwan

In this study, white matter abnormalities of attention-deficit hyperactivity disorder were investigated using diffusion tensor imaging. Two different algorithms, including the well-known voxel-based morphometry (VBM) method and recently proposed tract-based spatial statistics (TBSS), were applied for inter-subject comparison. 26 male adolescents (12 ADHD patients and 14 age-matching control subjects) were recruited in this study. Significant decrease of FA was observed on white matter tracts widespread in a scattering pattern by the use of both methods in patients compared to the control group.