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Abstract #2158

Grey Matter Abnormalities in Adult Attention Deficit/hyperactivity Disorder as Measured with Structural MRI

Natalia del Campo1,2, Julio Acosta-Cabronero3,4, Samuel R. Chamberlain, Dowson Jonathan5, Tim D. Fryer, 4, Trevor W. Robbins, Barbara J. Sahakian5, Ulrich Muller

1Psychiatry, University of Cambridge, Cambridge, Cambs, United Kingdom; 22Behavioural and Clinical Neuroscience Institute, Cambridge, Cambs, United Kingdom; 3Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom; 4Wolfson Brain Imaging Centre; 5Department of Psychiatry

Attention deficit/hyperactivity disorder (ADHD) is the most prevalent psychiatric disorder in children. To date, little is known about the persistence and stability of anatomical changes in ADHD across the lifespan. 16 adult ADHD patients and 17 healthy controls undertook structural magnetic resonance imaging. Using cluster-based permutation analysis we found that ADHD patients had reduced grey matter density in distributed circuitries including the right inferior and middle frontal cortex, as well as bilateral putamen, hippocampus, amygdala and cerebellum. These findings add to a growing body of evidence implicating abnormalities in fronto-striatal, fronto-cerebellar and limbic circuitries in ADHD.