Natalia del Campo1,2, Julio Acosta-Cabronero3,4,
Samuel R. Chamberlain, Dowson Jonathan5, Tim D. Fryer, 4,
Trevor W. Robbins, Barbara J. Sahakian5, Ulrich Muller
1Psychiatry, University of Cambridge,
Cambridge, Cambs, United Kingdom; 22Behavioural and Clinical
Neuroscience Institute, Cambridge, Cambs, United Kingdom; 3Department
of Clinical Neurosciences, University of Cambridge, Cambridge, United
Kingdom; 4Wolfson Brain Imaging Centre; 5Department of
Psychiatry
Attention
deficit/hyperactivity disorder (ADHD) is the most prevalent psychiatric
disorder in children. To date, little is known about the persistence and
stability of anatomical changes in ADHD across the lifespan. 16 adult ADHD
patients and 17 healthy controls undertook structural magnetic resonance
imaging. Using cluster-based permutation analysis we found that ADHD patients
had reduced grey matter density in distributed circuitries including the
right inferior and middle frontal cortex, as well as bilateral putamen,
hippocampus, amygdala and cerebellum. These findings add to a growing body of
evidence implicating abnormalities in fronto-striatal, fronto-cerebellar and
limbic circuitries in ADHD.