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Abstract #2159

A Systematic Analysis of Association Fiber Tracts in Chronic Alcoholics Found Significant Deficit of White Matter Integrity in Superior Longitudinal Fasciculus Using Diffusion Spectrum Imaging Tractography

Cheng-Liang Liu1, I-Chao Liu2, Wen-Yang Chiang3, Fang-Cheng Yeh4, Li-Wei Kuo1, Wen-Yih Isaac Tseng1,5

1Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan; 2School of Medicine, Fu Jen Catholic University, Taipei, Taiwan; 3The Methodist Hospital Research Institute, Weill Medical College of Cornell University, Houston, TX, United States; 4Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United States; 5Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan

In this study, we investigated the relationship between the effect of alcoholic use and the microstructural alteration of seven association fiber tracts using diffusion spectrum imaging tractography and tract-specific analysis. The metric of generalized fractional anisotropy (GFA) was used to identify the difference between control and alcoholic groups. Among all the association fiber tracts, a significant GFA deficit was found in bilateral superior longitudinal fasciculus for chronic alcoholics. A future study to analyze the segmented parts of the tract is needed to further reveal the subtle change of microstructural alteration of association fiber tracts in alcoholism.