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Abstract #2160

Frontal White Matter Choline-Containing Compounds Increase with Alcohol Consumption and Glutamate Decreases with Increasing Addiction Criteria

Gabriele Ende1, Derik Hermann2, Mareen Hoerst1, Nuran Tunc-Skarka1, Gunilla Oberthuer1, Svenja Wichert2, Juri Rabinstein2, Wolfgang Weber-Fahr1, Karl Mann2, Sabine Vollstaedt-Klein2

1Neuroimaging, Central Institute of Mental Health, Mannheim, Germany; 2Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany

With this 1H MRS study we aimed to investigate correlations between frontal white matter choline-containing compounds and glutamate with alcohol consumption and addictions scores in heavy drinking as well as in non-abstinent alcohol dependent patients. A positive correlation of choline-containing compounds and alcohol consumption could be replicated but the high variance could not be explained by addiction criteria (OCDS, ICD-10 and DSM IV). However, measures of addiction showed significant negative correlations with glutamate in the heavy drinking groups.