Jannie Petra Wijnen1, Tom W.J. Scheenen1, Arend Heerschap1
1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands
We demonstrated the clinical feasibility of combined 1H and 31P MRSI with sensitivity enhancement by polarisation transfer of 1H to 31P spins of human brain tumours at 3T to uncover the composition of (phosphorylated)choline and phosphorylated ethanolamine compounds in the membrane. Preliminary results from 4 patients with different tumour types show potentially important differences among tumours. This opens a window on a detailed view of the levels of some key metabolites in membrane phospholipid metabolism of human tumours.