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Abstract #2179

Combined 31P and 1H Magnetic Resonance Spectroscopic Imaging of Phosphomono and -Diesters in Human Brain Tumors at 3T.

Jannie Petra Wijnen1, Tom W.J. Scheenen1, Arend Heerschap1

1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands

We demonstrated the clinical feasibility of combined 1H and 31P MRSI with sensitivity enhancement by polarisation transfer of 1H to 31P spins of human brain tumours at 3T to uncover the composition of (phosphorylated)choline and phosphorylated ethanolamine compounds in the membrane. Preliminary results from 4 patients with different tumour types show potentially important differences among tumours. This opens a window on a detailed view of the levels of some key metabolites in membrane phospholipid metabolism of human tumours.