Abstract #2180

Multi-Echo Time Approach for Study of Metabolic Profiles in Brain Tumors at 3T

Changho Choi¹, Ivan Dimitrov^1,2, Deborah Douglas¹, Aditya Patel¹, Hao Huang¹, Ralph Deberardinis³, Juan Pascual⁴, Robert Bachoo⁵, Craig Malloy¹, Elizabeth Maher⁶

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; ²Philips Medical Systems, Cleveland, OH, United States; ³Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States; ⁴Neurology, Physiology and Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States; ⁵Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States; ⁶Internal Medicine and Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States

Echo time dependence of coupled-spin metabolites following point-resolved spectroscopy (PRESS) at 3T has been investigated with computer simulations. Three pairs of PRESS subecho times, (TE1, TE2) = (32, 22), (32, 80), and (32, 214) ms, were selected for optimum selectivity of glutamate and glutamine, and used for in vivo measurements of metabolites in brain tumors. We present preliminary in vivo results that show pronounced abnormalities of metabolic profiles, including elevated glutamine and glycine in glioblastoma multiforme and differentiation between lipids and lactate in low- and high-grade gliomas.