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Abstract #2181

In Vivo MRI of MR-Labeled Neural Stem Cell Migration to Gliomas

Bensheng Qiu1, Daohai Xie2, Piotr Walczak3, Xubin Li, Jesus Ruiz-Cabello3, Satoshi Minoshima, Jeff W.M. Bulte3, Xiaoming Yang

1University of Washington, Seattle, WA, United States; 2Radiology, Suzhou University School of Medicine; 3The Johns Hopkins University

Neural stem cells (NSC) have been recognized as cellular vehicles for treatment of invasive brain tumors. MRI is a unique non-invasive tool to monitor the migration of stem cells labeled with MR contrast agents, such as superparamagnetic iron oxide (SPIO) particles. Pervious studies have confirmed that magnetosonoporation (MSP) can instantly labeled SPIO into stem cells. The aim of this study was to validate the feasibility of MRI of MSP-labeled NSC migration to gliomas in vivo.