Anitha Priya Krishnan1, Delphine Davis2,
Paul Okunieff3, Walter G. O'Dell3
1Biomedical Engineering, University of
Rochester, Rochester, NY, United States; 2Imaging Sciences,
University of Rochester, Rochester, NY, United States; 3Radiation
Oncology, University of Rochester, Rochester, NY, United States
The
current methods for determining the treatment margins for stereotactic
radiotherapy of gliomas is inadequate as the tumor often recurs at the
boundary of the treatment margin. The areas of high normalized cell migration
predicted by our random walk model coincide with the direction along which
the tumor recurs. Here we have established that there is a statistically
significant correlation between the model predictions and the recurrence site
and the average normalized cell concentration in the recurrence site is
higher than the normalized cell concentration in 78% of the voxels on a
surface equidistant from the primary tumor surface.