Meeting Banner
Abstract #2184

Decreased Cerebral Oxygen Extraction Fraction (OEF) Measured by MR QBOLD Following Stereotactic Radiosurgery (SRS) in Patients with Metastatic Brain Tumors

Parinaz Massoumazdeh1, Xiang He1, Sarah Jost2, Keith Rich3, Dmitriy Yablonskiy1, Tammie Benzinger4

1Mallinckrodt Institute of Radiology, Washington University in Saint Louis; 2Swedish Hospital, Seattle, WA, United States; 3Neurosurgery, Washington University in Saint Louis; 4Mallinckrodt Institute of Radiology, Washington University in Saint Louis, St. Louis, MO, United States

There is growing evidence that solid organ tumors with ability to grow in hypoxic conditions demonstrate resistance to conventional chemotherapy and radiation therapy. Here, we used MR qBOLD technique to measure the OEF of metastatic brain tumors before and after SRS. In this population, OEF of both the tumors and peritumoral edema prior to SRS was elevated. Following SRS, OEF decreased in the areas of lesions. This suggests that qBOLD OEF may provide a new method to monitor brain tumor response to therapy.