Parinaz Massoumazdeh1, Xiang He1,
Sarah Jost2, Keith Rich3, Dmitriy Yablonskiy1,
Tammie Benzinger4
1Mallinckrodt Institute of Radiology,
Washington University in Saint Louis; 2Swedish Hospital, Seattle,
WA, United States; 3Neurosurgery, Washington University in Saint
Louis; 4Mallinckrodt Institute of Radiology, Washington University
in Saint Louis, St. Louis, MO, United States
There
is growing evidence that solid organ tumors with ability to grow in hypoxic
conditions demonstrate resistance to conventional chemotherapy and radiation
therapy. Here, we used MR qBOLD
technique to measure the OEF of metastatic brain tumors before and after
SRS. In this population, OEF of both
the tumors and peritumoral edema prior to SRS was elevated. Following SRS, OEF decreased in the areas
of lesions. This suggests that qBOLD
OEF may provide a new method to monitor brain tumor response to therapy.
Keywords