Ulrich
Pilatus1, Joerg Magerkurth1, Oliver Bhr2,
Joachim Steinbach2, Elke Hattingen1
1Institute of Neuroradiology,
University Hospital, Goethe-University, Frankfurt, Germany; 2Senckenbergisches
Institute of Neurooncology, University Hospital, Goethe University
Proton
and 31P MRSI was performed on human malignant recurrent gliomas in order to
provide in vivo analysis of membrane metabolism and neuronal brain damage
(tNAA). Phosphorylated components in the membrane metabolism showed clear
changes indicating a shift to proliferating cell fractions. While the increase in the
phosphocholine/glycerophosphocholine ratio in tumor tissue did not reach
significance (p=0.07) the respective ratio for the ethanolamine compound was
clearly significant (p=0.02). Further, the significant increase in the
inorganic-phosphate/phosphocreatine ratio hints to limited energy supply
within the tumor.
Keywords