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Abstract #2206

31P and 1H Spectroscopic Imaging of Recurrent Malignant Gliomas

Ulrich Pilatus1, Joerg Magerkurth1, Oliver Bhr2, Joachim Steinbach2, Elke Hattingen1

1Institute of Neuroradiology, University Hospital, Goethe-University, Frankfurt, Germany; 2Senckenbergisches Institute of Neurooncology, University Hospital, Goethe University

Proton and 31P MRSI was performed on human malignant recurrent gliomas in order to provide in vivo analysis of membrane metabolism and neuronal brain damage (tNAA). Phosphorylated components in the membrane metabolism showed clear changes indicating a shift to proliferating cell fractions. While the increase in the phosphocholine/glycerophosphocholine ratio in tumor tissue did not reach significance (p=0.07) the respective ratio for the ethanolamine compound was clearly significant (p=0.02). Further, the significant increase in the inorganic-phosphate/phosphocreatine ratio hints to limited energy supply within the tumor.