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Abstract #2218

Evolution of Fractional Anisotropy in Hyperacute Ischemic Stroke

Ashley D. Harris1,2, Linda B. Andersen, 2,3, Robert K. Kosior, 2,4, Henry Chen, 2,5, Marina Salluzzi, 2,4, Randall B. Stafford, 2,5, Bradley G. Goodyear, 2,3, Richard Frayne, 2,3

1School of Psychology, CUBRIC, Cardiff University, Cardiff, United Kingdom; 2Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada; 3Clinical Neurosciences and Radiology, Univerisity of Calgary, Calgary, Alberta, Canada; 4Biomedical Engineering, Univerisity of Calgary, Calgary, Alberta, Canada; 5Physics, Univerisity of Calgary, Calgary, Alberta, Canada

Diffusion-weighted images and apparent diffusion coefficient maps are widely used in ischemic stroke detection; however, additional information may be available from diffusion imaging in the assessment of hyperacute ischemic stroke. In this study, fractional anisotropy was examined during hyperacute ischemic stroke (06h from onset) in a canine model. White matter shows a biphasic FA response; an initial increase followed by a decrease. Grey matter showed FA increases. The timing and magnitude of these FA changes appears to be related to stroke severity. With thorough understanding of these changes, FA may be useful in treatment decisions for stroke patients.