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Abstract #2219

Apparent Kurtosis and Fractional Anisotropy Potentially Predicts Tissue Outcome in Sub-Acute Stroke

Danielle van Westen1,2, Markus Nilsson3, Hkan Sjunnesson1,2, Freddy Sthlberg, 2,3, Sara Brockstedt4, Ronnie Wirestam3, Jimmy Ltt1,3

1Center for Medical Imaging and Physiology, Lund University Hospital, Lund, Sweden; 2Department of Diagnostic Radiology, Lund University, Lund, Sweden; 3Department of Medical Radiation Physics, Lund University, Lund, Sweden; 4Radiation Physics, Lund University Hospital, Lund, Sweden

Diffusion measurements were performed 2, 9 and 90 days after stroke onset, estimating the mean diffusivity (MD), the apparent diffusion kurtosis (ADK) and the fractional anisotropy (FA). Tissue outcome at day 90 was dependent on tissue type, i.e. white- or grey matter, as well as location. For instance, deep white matter developed gliosis, while subcortical U-fibres pseudonormalized. FA and ADK obtained at day 2 predicted the tissue outcome at day 90 in white matter.