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Abstract #2229

Regional Delta-Diffusion Analysis of the Brain During Cardiac Cycle in Idiopathic Normal Pressure Hydrocephalus

Naoki Ohno1,2, Tosiaki Miyati2, Mitsuhito Mase3, Hirohito Kan2, Harumasa Kasai4, Masaki Hara4, Yuta Shibamoto4, Kazuo Yamada3, Akihiro Kitanaka2, Tomoyuki Yamamoto1

1Department of Radiological Technology, Kanazawa University Hospital, Kanazawa, Japan; 2Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan; 3Department of Neurosurgery and Restorative Neuroscience, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan; 4Department of Radiology, Nagoya City University Hospital, Nagoya, Japan

There have been many unsolved problems with this syndrome in terms of the diagnostic criteria and selection of appropriate patients for shunt surgery. To evaluate the intracranial condition of the brain in idiopathic normal-pressure hydrocephalus (I-NPH), we determined the change in the apparent diffusion coefficient of the brain during the cardiac cycle (delta-ADC). Delta-ADC analysis makes it possible to noninvasively obtain new and more detailed information on the intracranial condition in I-NPH and thereby assist in the diagnosis.