Abstract #2229

Regional Delta-Diffusion Analysis of the Brain During Cardiac Cycle in Idiopathic Normal Pressure Hydrocephalus

Naoki Ohno^1,2, Tosiaki Miyati², Mitsuhito Mase³, Hirohito Kan², Harumasa Kasai⁴, Masaki Hara⁴, Yuta Shibamoto⁴, Kazuo Yamada³, Akihiro Kitanaka², Tomoyuki Yamamoto¹

¹Department of Radiological Technology, Kanazawa University Hospital, Kanazawa, Japan; ²Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan; ³Department of Neurosurgery and Restorative Neuroscience, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan; ⁴Department of Radiology, Nagoya City University Hospital, Nagoya, Japan

There have been many unsolved problems with this syndrome in terms of the diagnostic criteria and selection of appropriate patients for shunt surgery. To evaluate the intracranial condition of the brain in idiopathic normal-pressure hydrocephalus (I-NPH), we determined the change in the apparent diffusion coefficient of the brain during the cardiac cycle (delta-ADC). Delta-ADC analysis makes it possible to noninvasively obtain new and more detailed information on the intracranial condition in I-NPH and thereby assist in the diagnosis.